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Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder and as an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that features a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and still have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular physical activity. Results from a clinical trial that enrolled patients without diabetes demonstrated that patients had the average weight loss of four years old.1% instead of participants who have been given placebos) during a 12- month period, while a different study involving patients with diabetes type 2 had a typical weight loss of 2% over treatment with placebo at one year. Using two separate drugs to lose weight naturally can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people that go through it one should err on the side of caution and allow the FDA do its job and demand some investigation be done so the public knows the side effects and hazards of the medications before we take them. Keep in mind that drug companies are in business to generate money and that they would say everything to keep people on his or her medications. Researchers found out that participants investing in this drug for any year, dropped a few pounds within a month and have kept the weight off through the entire 56 weeks in the study. Contrave is really a combination in the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs that are made up of several active ingredient, which might make them more effective and safer. Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and therefore it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular will be the fact that since right now there aren't long term prescription diet pills that have been authorized by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug also can raise hypertension and heart rate, and must not be used in individuals with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure levels and heart rate and must 't be used in patients with uncontrolled high blood pressure levels, as well as by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients having a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients towards the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation. "This could be the first drug I'm conscious of that targets both the appetite and reward centres in the brain," he was quoted saying.