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Using two separate drugs to lose weight naturally can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with fat loss and the people that go through it you need to err on the side of caution and allow FDA do its job and demand some investigation be done so that the public recognizes the side effects and dangers of the medications before we take them. Keep in mind that drug companies come in business to earn money and that they would say almost anything to keep people on their medications. Researchers found that participants investing in this drug for any year, lost excess weight within four weeks and have kept the load off throughout the 56 weeks from the study. Contrave is really a combination of the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which are made up of more than one active ingredient, which may make them more efficient and safer. Combo-pilling may be the newest fad or better yet the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that by right now there are no long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug may also raise blood pressure level and heartrate, and really should not be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and pulse rate and must 't be used in patients with uncontrolled high hypertension, as well as by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking. From a psychiatric point of view, evidence suggests that the ordinary neural mechanism for goal-directed behavior has been hijacked with the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object creates a stimulus as well as the person engages in a "goal-directed behavioral response" that generates a "natural high"(Bostwick & Bucci, 2008).